1. The Hsp60 monomer has three distinct sections separated by two hinge regions . 2. This region has been termed the hinge region . 3. Thus, the IgA protease act by cleaving the proline-rich hinge region of the heavy chain of IgA1. 4. Direct acetylation of the estrogen receptor alpha at the lysine residues in hinge region by p300 regulates transactivation and hormone sensitivity. 5. Even though there is about 95 % similarity between their Fc regions, the structure of the hinge regions is relatively different. 6. Conserved Region 3 ( CR3 ), residues 457 717, is bi-lobal, connected by a short hinge region . 7. Structurally hemopexin consists of two similar halves of approximately two hundred amino acid residues connected by a histidine-rich hinge region . 8. The LAP complex contains a protease-sensitive hinge region which can be the potential target for this liberation of TGF-?. 9. SMIPs are single-chain proteins that comprise one binding region, one hinge region as a connector, and one effector domain. 10. To produce an F ( ab') 2 fragment, IgG is digested with pepsin, which cleaves the heavy chains near the hinge region . 
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